Emerging targets in human lymphoma: targeting the MYD88 mutation

B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid substitution of proline for the leucine at position 265 (L265P), and the exact same variant has also been identified in a number of lymphoid malignancies. The MYD88 L265P variant was recently identified in 90% of Wadenstrom's macroglobulinemia patients. These recent developments warrant the need for novel diagnostic tools as well as targeted therapeutics. In this review, we discuss the physiological functions of MYD88 and focus on its role in B cell lymphomas, evaluating the potential for targeting oncogenic MYD88 in lymphoma

Stability Analysis of Optimal Velocity Model for Traffic and Granular Flow under Open Boundary Condition

We analyzed the stability of the uniform flow solution in the optimal velocity model for traffic and granular flow under the open boundary condition. It was demonstrated that, even within the linearly unstable region, there is a parameter region where the uniform solution is stable against a localized perturbation. We also found an oscillatory solution in the linearly unstable region and its period is not commensurate with the periodicity of the car index space. The oscillatory solution has some features in common with the synchronized flow observed in real traffic.Comment: 4 pages, 6 figures. Typos removed. To appear in J. Phys. Soc. Jp

Relativistic Hartree approach with exact treatment of vacuum polarization for finite nuclei

We study the relativistic Hartree approach with the exact treatment of the vacuum polarization in the Walecka sigma-omega model. The contribution from the vacuum polarization of nucleon-antinucleon field to the source term of the meson fields is evaluated by performing the energy integrals of the Dirac Green function along the imaginary axis. With the present method of the vacuum polarization in finite system, the total binding energies and charge radii of 16O and 40Ca can be reproduced. On the other hand, the level-splittings in the single-particle level, in particular the spin-orbit splittings, are not described nicely because the inclusion of vacuum effect provides a large effective mass with small meson fields. We also show that the derivative expansion of the effective action which has been used to calculate the vacuum contribution for finite nuclei gives a fairly good approximation.Comment: 15 pages, 8 figure

Investigation of environmental change pattern in Japan

The author has identified the following significant results. A detailed land use classification for a large urban area of Tokyo was made using MSS digital data. It was found that residential, commercial, industrial, and wooded areas and grasslands can be successfully classified. A mesoscale vortex associated with large ocean current, Kuroshio, which is a rare phenomenon, was recognized visually through the analysis of MSS data. It was found that this vortex affects the effluent patterns of rivers. Lava flowing from Sakurajima Volcano was clearly classified for three major erruptions (1779, 1914, and 1946) using MSS data

4/3-Law of Granular Particles Flowing through a Vertical Pipe

Density waves of granular material (sand) flowing through a vertical pipe have been investigated. Clear density waves emerge when the cock attached to bottom end of the pipe is closed. The FFT power spectra were found to show a stable power-law form $P(f) \sim f^{-\alpha}.$ The value of the exponent was evaluated as $\alpha \cong 4/3$. We also introduce a simple one-dimensional model which reproduces $\alpha = 4/3$ from both simulation and theoretical analysis. (to be published in Phys.Rev.Lett.)Comment: 4 pages, 4 figures, a style fil

Feasibility of high-voltage systems for a very long drift in liquid argon TPCs

Designs of high-voltage (HV) systems for creating a drift electric field in liquid argon TPCs are reviewed. In ongoing experiments systems capable of approx. 100 kV are realised for a drift field of 0.5-1 kV/cm over a length of up to 1.5 m. Two of them having different approaches are presented: (1) the ICARUS-T600 detector having a system consisting of an external power supply, HV feedthroughs and resistive voltage degraders and (2) the ArDM-1t detector having a cryogenic Greinacher HV multiplier inside the liquid argon volume. For a giant scale liquid argon TPC, a system providing 2 MV may be required to attain a drift length of approx. 20 m. Feasibility of such a system is evaluated by extrapolating the existing designs.Comment: 8 pages, 13 figures, to appear in Proc. of 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Tsukuba (Japan), March 201

Instability of dilute granular flow on rough slope

We study numerically the stability of granular flow on a rough slope in collisional flow regime in the two-dimension. We examine the density dependence of the flowing behavior in low density region, and demonstrate that the particle collisions stabilize the flow above a certain density in the parameter region where a single particle shows an accelerated behavior. Within this parameter regime, however, the uniform flow is only metastable and is shown to be unstable against clustering when the particle density is not high enough.Comment: 4 pages, 6 figures, submitted to J. Phys. Soc. Jpn.; Fig. 2 replaced; references added; comments added; misprints correcte

First operation and drift field performance of a large area double phase LAr Electron Multiplier Time Projection Chamber with an immersed Greinacher high-voltage multiplier

We have operated a liquid-argon large-electron-multiplier time-projection chamber (LAr LEM-TPC) with a large active area of 76 $\times$ 40 cm$^2$ and a drift length of 60 cm. This setup represents the largest chamber ever achieved with this novel detector concept. The chamber is equipped with an immersed built-in cryogenic Greinacher multi-stage high-voltage (HV) multiplier, which, when subjected to an external AC HV of $\sim$1 kV$_{\mathrm{pp}}$, statically charges up to a voltage a factor of $\sim$30 higher inside the LAr vessel, creating a uniform drift field of $\sim$0.5 kV/cm over the full drift length. This large LAr LEM-TPC was brought into successful operation in the double-phase (liquid-vapor) operation mode and tested during a period of $\sim$1 month, recording impressive three-dimensional images of very high-quality from cosmic particles traversing or interacting in the sensitive volume. The double phase readout and HV systems achieved stable operation in cryogenic conditions demonstrating their good characteristics, which particularly suit applications for next-generation giant-scale LAr-TPCs.Comment: 26 pages, 19 figure